[¹²⁴I]CLR1404 PET/CT in High-Grade Primary and Metastatic Brain Tumors.

ABSTRACT:

Purpose

There is a continuous search for imaging techniques with high sensitivity and specificity for brain tumors. Positron emission tomography (PET) imaging has shown promise, though many PET agents either have a low tumor specificity or impractical physical half-lives. [¹²⁴I]CLR1404 is a small molecule alkylphosphocholine analogue that is thought to bind to plasma membrane lipid rafts and has shown high tumor-to-background ratios (TBR) in a previous pilot study in brain tumor patients. This study attempts to define the clinical value of [¹²⁴I]CLR1404 PET/CT (aka CLR124).

Procedures

Adult patients with new or suspected recurrence of high-grade primary or metastatic brain tumors (N = 27) were injected with [¹²⁴I]CLR1404 followed by PET/CT at

SUBMITTER: Hall LT 

PROVIDER: S-EPMC7485611 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature