Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota.

ABSTRACT: Multiple epidemiological studies identify Dolosigranulum pigrum as a candidate beneficial bacterium based on its positive association with health, including negative associations with nasal/nasopharyngeal colonization by the pathogenic species Staphylococcus aureus and Streptococcus pneumoniae Using a multipronged approach to gain new insights into D. pigrum function, we observed phenotypic interactions and predictions of genomic capacity that support the idea of a role for microbe-microbe interactions involving D. pigrum in shaping the composition of human nasal microbiota. We identified in vivo community-level and in vitro phenotypic cooperation by specific nasal Corynebacterium species. Also, D. pigrum inhibited S. aureus

SUBMITTER: Brugger SD 

PROVIDER: S-EPMC7485692 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature