RPP30, a transcriptional regulator, is a potential pathogenic factor in glioblastoma.

ABSTRACT:

Background

Old age has been demonstrated to be a risk factor for GBM, but the underlying biological mechanism is still unclear. We designed this study intending to determine a mechanistic explanation for the link between age and pathogenesis in GBM.

Results

The expression of RPP30, an independent prognostic factor in GBM, was negatively correlated with age in both tumor and non-tumor brain samples. However, the post-transcriptional modifications carried out by RPP30 were different in primary GBM and non-tumor brain samples. RPP30 affected protein expression of cancer pathways by performing RNA modifications. Further, we found that RPP30 was related to drug metabolism pathways important in GBM. The decreased expression of RPP30 in older patients might be a pathogenic factor f

SUBMITTER: Li G 

PROVIDER: S-EPMC7485703 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature