Abnormal static and dynamic functional connectivity of resting-state fMRI in multiple system atrophy.

ABSTRACT: In order to explore the topological alterations in functional brain networks between multiple system atrophy (MSA) patients and healthy controls (HC), a new joint analysis method of static and dynamic functional connectivity (FC) is proposed in this paper. Twenty-four MSA patients and twenty HCs were enrolled in this study. We constructed static and dynamic brain networks from resting-state fMRI data and calculated four graph theory attributes. Statistical comparisons and correlation analysis were carried out for static and dynamic FC separately before combining both cases. We found decreased local efficiency (LE) and weighted degree (WD) in cerebellum from both static and dynamic graph attributes. For static FC alone, we identified increased betweenness centrality (BC) at left dorsolatera

SUBMITTER: Zheng W 

PROVIDER: S-EPMC7485713 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature