Autoantibodies against M₅-muscarinic and beta₁-adrenergic receptors in periodontitis patients.

ABSTRACT: Autoantibodies against muscarinic and beta₁-adrenergic receptors are considered a potential cause and/or risk factor for chronic heart failure. Association of periodontitis with such autoantibodies and with impaired heart function has been observed in patients exposed to endemic Chagas' disease, which triggers by itself cardiomyopathy and receptor immunization.Here we studied the association between periodontitis, markers of cardiac injury and receptor autoimmunization in periodontitis patients (n = 147) not exposed to Chagas' disease. The autoantibodies were determined by IgG binding to native intact muscarinic and beta₁-adrenergic receptors or to a cyclic peptide mimicking the disease-relevant conformational autoepitope presented by the active beta₁-adren

SUBMITTER: Scherbaum I 

PROVIDER: S-EPMC7485715 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature