The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.

ABSTRACT:

Background

A number of epidemiological and genetic studies have attempted to determine whether levels of circulating lipids are associated with risks of various cancers, including breast cancer (BC). However, it remains unclear whether a causal relationship exists between lipids and BC. If alteration of lipid levels also reduced risk of BC, this could present a target for disease prevention. This study aimed to assess a potential causal relationship between genetic variants associated with plasma lipid traits (high-density lipoprotein, HDL; low-density lipoprotein, LDL; triglycerides, TGs) with risk for BC using Mendelian randomization (MR).

Methods and findings

Data from genome-wide association studies in up to 215,551 participants from the Million Veteran Program (MVP) wer

SUBMITTER: Johnson KE 

PROVIDER: S-EPMC7485834 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature