Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults.

ABSTRACT: Converging evidence suggests a relationship between aerobic exercise and hippocampal neuroplasticity that interactively impacts hippocampally dependent memory. The majority of human studies have focused on the potential for exercise to reduce brain atrophy and attenuate cognitive decline in older adults, whereas animal studies often center on exercise-induced neurogenesis and hippocampal plasticity in the dentate gyrus (DG) of young adult animals. In the present study, initially sedentary young adults (18-35 years) participated in a moderate-intensity randomized controlled exercise intervention trial (ClinicalTrials.gov; NCT02057354) for a duration of 12 weeks. The aims of the study were to investigate the relationship between change in cardiorespiratory fitness (CRF) as determined by esti

SUBMITTER: Nauer RK 

PROVIDER: S-EPMC7485880 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature