Executable biochemical space for specification and analysis of biochemical systems.

ABSTRACT: Computational systems biology provides multiple formalisms for modelling of biochemical processes among which the rule-based approach is one of the most suitable. Its main advantage is a compact and precise mechanistic description of complex processes. However, state-of-the-art rule-based languages still suffer several shortcomings that limit their use in practice. In particular, the elementary (low-level) syntax and semantics of rule-based languages complicate model construction and maintenance for users outside computer science. On the other hand, mathematical models based on differential equations (ODEs) still make the most typical used modelling framework. In consequence, robust re-interpretation and integration of models are difficult, thus making the systems biology paradigm technica

SUBMITTER: Trojak M 

PROVIDER: S-EPMC7485897 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature