Pharmacogenomics in Asian Subpopulations and Impacts on Commonly Prescribed Medications.

ABSTRACT: Asians as a group comprise > 60% the world's population. There is an incredible amount of diversity in Asian and admixed populations that has not been addressed in a pharmacogenetic context. The known pharmacogenetic differences in Asian subgroups generally represent previously known variants that are present at much lower or higher frequencies in Asians compared with other populations. In this review we summarize the main drugs and known genes that appear to have differences in their pharmacogenetic properties in certain Asian populations. Evidence-based guidelines and summary statistics from the US Food and Drug Administration and the Clinical Pharmacogenetics Implementation Consortium were analyzed for ethnic differences in outcomes. Implicated drugs included commonly prescribed drugs s

SUBMITTER: Lo C 

PROVIDER: S-EPMC7485947 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature