Creatinine Fluctuations Forecast Cross-Harvest Kidney Function Decline Among Sugarcane Workers in Guatemala.

ABSTRACT:

Background

Chronic kidney disease of unknown origin (CKDu) is an epidemic that disproportionately affects young agriculture workers in hot regions. It has been hypothesized that repeated acute kidney injury (AKI) may play a role in the development of disease.

Methods

Latent class mixed models were used to identify groups of Guatemalan sugarcane harvesters based on their daily changes in creatinine over 6 consecutive days in 2018. Exponential smoothing state space models were used to forecast end-of-season creatinine between the identified groups. Percent change in estimated glomerular filtration rate (eGFR) across the harvest was compared between groups.

Results

Twenty-nine percent (n = 30) of the 103 workers experienced repeated severe fluctuations in creatinine acro

SUBMITTER: Dally M 

PROVIDER: S-EPMC7486184 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature