A Causal Network Analysis of Neuromodulation in the Mood Processing Network.

ABSTRACT: Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication, whereas sbTetMS neuromodulation temporarily disrupted sender-receiver communication. These results r

SUBMITTER: Qiao S 

PROVIDER: S-EPMC7486259 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature