Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis.

ABSTRACT:

Rationale

Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose variations, termed transient intermittent hyperglycemia (TIH), appear to be an independent risk factor for cardiovascular disease, but the pathological basis for this association is unclear.

Objective

To determine whether TIH per se promotes myelopoiesis to produce more monocytes and consequently adversely affects atherosclerosis.

Methods and results

To create a mouse model of TIH, we administered 4 bolus doses of glucose at 2-hour intervals intraperitoneally once to WT (wild

SUBMITTER: Flynn MC 

PROVIDER: S-EPMC7486277 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature