Type 2-high asthma is associated with a specific indoor mycobiome and microbiome.

ABSTRACT:

Background

The links between microbial environmental exposures and asthma are well documented, but no study has combined deep sequencing results from pulmonary and indoor microbiomes of patients with asthma with spirometry, clinical, and endotype parameters.

Objective

The goal of this study was to investigate the links between indoor microbial exposures and pulmonary microbial communities and to document the role of microbial exposures on inflammatory and clinical outcomes of patients with severe asthma (SA).

Methods

A total of 55 patients with SA from the national Cohort of Bronchial Obstruction and Asthma cohort were enrolled for analyzing their indoor microbial flora through the use of electrostatic dust collectors (EDCs). Among these patients, 22 were able to prod

SUBMITTER: Vandenborght LE 

PROVIDER: S-EPMC7486598 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature