A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature.

ABSTRACT: Microglia, a resident CNS macrophage, are dynamic cells, constantly extending and retracting their processes as they contact and functionally regulate neurons and other glial cells. There is far less known about microglia-vascular interactions, particularly under healthy steady-state conditions. Here, we use the male and female mouse cerebral cortex to show that a higher percentage of microglia associate with the vasculature during the first week of postnatal development compared with older ages and that the timing of these associations is dependent on the fractalkine receptor (CX3CR1). Similar developmental microglia-vascular associations were detected in the human brain. Using live imaging in mice, we found that juxtavascular microglia migrated when microglia are actively colonizing the

SUBMITTER: Mondo E 

PROVIDER: S-EPMC7486666 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature