Testosterone and hippocampal trajectories mediate relationship of poverty to emotion dysregulation and depression.

ABSTRACT: There is robust evidence that early poverty is associated with poor developmental outcomes, including impaired emotion regulation and depression. However, the specific mechanisms that mediate this risk are less clear. Here we test the hypothesis that one pathway involves hormone mechanisms (testosterone and DHEA) that contribute to disruption of hippocampal brain development, which in turn contributes to perturbed emotion regulation and subsequent risk for depression. To do so, we used data from 167 children participating in the Preschool Depression Study, a longitudinal study that followed children from preschool (ages 3 to 5 y) to late adolescence, and which includes prospective assessments of poverty in preschool, measures of testosterone, DHEA, and hippocampal volume across school age

SUBMITTER: Barch DM 

PROVIDER: S-EPMC7486761 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature