β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.

ABSTRACT: The γδ T cells reside predominantly at barrier sites and play essential roles in immune protection against infection and cancer. Despite recent advances in the development of γδ T cell immunotherapy, our understanding of the basic biology of these cells, including how their numbers are regulated in vivo, remains poor. This is particularly true for tissue-resident γδ T cells. We have identified the β₂ family of integrins as regulators of γδ T cells. β₂-integrin-deficient mice displayed a striking increase in numbers of IL-17-producing Vγ6Vδ1⁺ γδ T cells in the lungs, uterus, and circulation. Thymic development of this population was normal. However, single-cell RNA sequencing revealed the enrichment of genes associated with T cell survival and proliferation

SUBMITTER: McIntyre CL 

PROVIDER: S-EPMC7486781 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature