Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019.

ABSTRACT: Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.

SUBMITTER: Patel M 

PROVIDER: S-EPMC7486855 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature