Systematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity.

ABSTRACT: The woman's gut microbiota during pregnancy may support nutrient acquisition, is associated with diseases, and has been linked to infant health. However, there is limited information on gut microbial characteristics and dependence in pregnant women. In this study, we provide a comprehensive overview of the gut microbial characteristics of 1479 pregnant women using 16S rRNA gene sequencing of fecal samples. We identify a core microbiota of pregnant women, which displays a similar overall structure to that of age-matched nonpregnant women. Our data show that the gestational age-associated variation in the gut microbiota, from the ninth week of gestation to antepartum, is relatively limited. Building upon rich metadata, we reveal a set of exogenous and intrinsic host factors that are highly c

SUBMITTER: Yang H 

PROVIDER: S-EPMC7486914 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature