Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis.

ABSTRACT: Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to regenerate or replace functionally impaired tissues. Since the introduction of the induced pluripotent stem cell technology in 2006, the number of scientific publications on this topic has constantly been increasing. However, so far no therapy based on PSCs has found its way into routine clinical use. In this study, we examined research trends related to clinical trials involving PSCs based on data obtained from ClinicalTrials.gov, the ICTRP database from the World Health Organization, as well as from a search of all individual databases that are included in the ICTRP using a multistep search algorithm. Following a stringent inclusion/exclusion procedure 131 studies remained that could be classified as c

SUBMITTER: Deinsberger J 

PROVIDER: S-EPMC7486930 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature