Bortezomib consolidation or maintenance following immunochemotherapy and autologous stem cell transplantation for mantle cell lymphoma: CALGB/Alliance 50403.

ABSTRACT: Immunochemotherapy followed by autologous transplant (ASCT) in CALGB/Alliance 59909 achieved a median progression-free survival (PFS) in mantle cell lymphoma (MCL) of 5 years, but late recurrences occurred. We evaluated tolerability and efficacy of adding post-transplant bortezomib consolidation (BC) or maintenance (BM) to this regimen in CALGB/Alliance 50403, a randomized phase II trial. Following augmented-dose R-CHOP/ methotrexate, high-dose cytarabine-based stem cell mobilization, cyclophosphamide/carmustine/etoposide (CBV) autotransplant, and rituximab, patients were randomized to BC (1.3 mg/m² IV days 1, 4, 8, 11 of a 3-week cycle for four cycles) or BM (1.6 mg/m² IV once weekly × 4 every 8 weeks for 18 months) beginning day 90. The primary endpoint was PFS, mea

SUBMITTER: Kaplan LD 

PROVIDER: S-EPMC7486983 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature