Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency.

ABSTRACT:

Background

There is an unmet need for an objective biomarker to predict asthma exacerbations.

Objective

Our aim was to assess the ventilation defect percent (VDP) on hyperpolarized helium-3 magnetic resonance imaging as a predictor of exacerbation frequency following imaging.

Methods

Subjects underwent hyperpolarized helium-3 and conventional clinical measurements, including pulmonary function tests, during a period of disease stability, and exacerbations were recorded prospectively over the following 2 years. We used a Poisson regression tree model to estimate an optimal VDP threshold for classifying subjects into high- versus low-exacerbation groups and then used statistical regression to compare this VDP threshold against conventional clinical measures as predictor

SUBMITTER: Mummy DG 

PROVIDER: S-EPMC7487001 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature