Diverse types of genomic evidence converge on alcohol use disorder risk genes.

ABSTRACT:

Background

Alcohol use disorder (AUD) is one of the most common forms of substance use disorders with a strong contribution of genetic (50%-60%) and environmental factors. Genome-wide association studies (GWAS) have identified a number of AUD-associated variants, including those in alcohol metabolism genes. These genetic variants may modulate gene expression, making individuals more susceptible to AUD. A long-term alcohol consumption can also change the transcriptome patterns of subjects via epigenetic modulations.

Methods

To explore the interactive effect of genetic and epigenetic factors on AUD, we conducted a secondary analysis by integrating GWAS, CNV, brain transcriptome and DNA methylation data to unravel novel AUD-associated genes/variants. We applied the mega-analysi

SUBMITTER: Dai Y 

PROVIDER: S-EPMC7487038 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature