Analysis of the time-varying Cox model for the cause-specific hazard functions with missing causes.

ABSTRACT: This paper studies the Cox model with time-varying coefficients for cause-specific hazard functions when the causes of failure are subject to missingness. Inverse probability weighted and augmented inverse probability weighted estimators are investigated. The latter is considered as a two-stage estimator by directly utilizing the inverse probability weighted estimator and through modeling available auxiliary variables to improve efficiency. The asymptotic properties of the two estimators are investigated. Hypothesis testing procedures are developed to test the null hypotheses that the covariate effects are zero and that the covariate effects are constant. We conduct simulation studies to examine the finite sample properties of the proposed estimation and hypothesis testing procedures under

SUBMITTER: Heng F 

PROVIDER: S-EPMC7487047 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature