Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.

ABSTRACT:

Purpose

Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women with pathologically confirmed ovarian carcinoma was conducted to examine the association between MHT use prior to diagnosis and survival.

Methods

Data from 15 studies in the Ovarian Cancer Association Consortium were included. MHT use was examined by type (estrogen-only (ET) or estrogen+progestin (EPT)), duration, and recency of use relative to diagnosis. Cox proportional hazards models were used to estimate the association between hormone therapy use and survival. Logistic regression and mediation analysis was used to explor

SUBMITTER: Brieger KK 

PROVIDER: S-EPMC7487048 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature