Fine-Scale Position Effects Shape the Distribution of Inversion Breakpoints in Drosophila melanogaster.

ABSTRACT: Chromosomal inversions are among the primary drivers of genome structure evolution in a wide range of natural populations. Although there is an impressive array of theory and empirical analyses that have identified conditions under which inversions can be positively selected, comparatively little data are available on the fitness impacts of these genome structural rearrangements themselves. Because inversion breakpoints can disrupt functional elements and alter chromatin domains, the precise positioning of an inversion's breakpoints can strongly affect its fitness. Here, we compared the fine-scale distribution of low-frequency inversion breakpoints with those of high-frequency inversions and inversions that have gone to fixation between Drosophila species. We identified a number of differe

SUBMITTER: McBroome J 

PROVIDER: S-EPMC7487137 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature