The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods.

ABSTRACT: The solute carrier (SLC) transporter superfamily comprises an ancient and ubiquitous group of proteins capable of translocating a range of nutrients, endogenous molecules, and xenobiotics. Although the group has been the subject of intense investigation in both bacteria and mammals, its systematic identification in arthropods has not yet been undertaken. Here, we present a genome-wide identification of all 66 human SLC families in 174 arthropod species. A pipeline (SLC_id) was constructed to identify and group SLCs using a combination of hidden Markov model and BLAST searches followed by filtering based on polypeptide length and the number of transmembrane domains. Comparative analysis of the number of transporters in each family across diverse arthropod lineages was accomplished using one

SUBMITTER: Denecke SM 

PROVIDER: S-EPMC7487162 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature