Early antiretroviral therapy in HIV-infected infants: can it lead to HIV remission?

ABSTRACT: Interventions to prevent mother-to-child HIV transmission have been extremely successful, but new HIV infections continue to occur in infants. Strong evidence indicates that combination antiretroviral therapy (ART) for treatment should be started in HIV-infected infants to prevent early morbidity and mortality. In 2013, the report of the Mississippi baby, who was started on ART within 30 h of life and maintained off-treatment remission for 27 months before HIV was once again detectable, generated renewed interest in very early ART initiation. The case stimulated interest in the possibility of HIV remission, which we define as maintenance of plasma viraemia below the threshold of detection in the absence of ART, after early treatment initiation. The possibility of HIV remission elicits much

SUBMITTER: Shiau S 

PROVIDER: S-EPMC7487171 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature