Proprotein convertase subtilisin/kexin type 9 inhibition in cardiovascular disease: current status and future perspectives.

ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the degradation of low-density lipoprotein (LDL) receptors; it has been proved that its inhibition improves cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease (ASCVD). Herein, we review the current status of PCSK9 inhibitors in clinical practice and the future scope of PCSK9 inhibition. The results of two recent large clinical trials reveal that two PCSK9 monoclonal antibodies evolocumab and alirocumab reduce the risk of a cardiovascular event on top of background statin therapy in patients with stable ASCVD and those with recent acute coronary syndrome, respectively. However, there are several ongoing concerns regarding the efficacy in reducing mortality, cost-effectiveness, and long-ter

SUBMITTER: Cho KH 

PROVIDER: S-EPMC7487297 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature