Mediation effect of herpes zoster derived by statin use on cardiovascular disease risk.

ABSTRACT:

Background/aims

Although statins are widely used to reduce the risk of cardiovascular disease (CVD) including stroke and myocardial infarction (MI), it is reported that statin use increases the incidence of herpes zoster (HZ) that is associated with increased risk of CVD. So, we evaluated the mediation effect of HZ caused by statin use on CVD.

Methods

We analyzed a prospective cohort from the National Health Insurance Service-database of South Korea. All individuals received a medical check-up and were followed-up from 2002 to 2013.

Results

A total of 275,382 individuals > 40 years old were followed up for 11 years from 2003. Of these, 11,415 people (4%) were classified as statin users and 263,967 (96%) as non-statin users. Those who used statins had significantly low

SUBMITTER: Kim SH 

PROVIDER: S-EPMC7487315 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature