Dynamic Luminal Topography: A Potential Strategy to Prevent Vascular Graft Thrombosis.

ABSTRACT:

Aim

Biologic interfaces play important roles in tissue function. The vascular lumen-blood interface represents a surface where dynamic interactions between the endothelium and circulating blood cells are critical in preventing thrombosis. The arterial lumen possesses a uniform wrinkled surface determined by the underlying internal elastic lamina. The function of this structure is not known, but computational analyses of artificial surfaces with dynamic topography, oscillating between smooth and wrinkled configurations, support the ability of this surface structure to shed adherent material (Genzer and Groenewold, 2006; Bixler and Bhushan, 2012; Li et al., 2014). We hypothesized that incorporating a luminal surface capable of cyclical wrinkling/flattening during the cardiac cycle in

SUBMITTER: Nath NN 

PROVIDER: S-EPMC7487362 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature