Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica.

ABSTRACT:

Background

Hepatic granuloma formation and fibrosis as the consequence of tissue entrapped eggs produced by female schistosomes characterize the pathology of Schistosoma japonicum infection. It has been proposed that fucoidan, a sulfated polysaccharide existing naturally in brown seaweed Fucus vesiculosus, plays a diversified role to perform immunomodulatory activities. However, whether fucoidan functions in the host hepatic pathology is unknown and identifying the potential mechanism that is responsible for hepatic improvement is still necessary.

Methods

We evaluated the hepatic pathology from S. japonicum-infected mice after treatment with fucoidan. qRT-PCR and immunofluorescence were used to detect the pro- or anti-inflammatory factors and the phosphorylated p65 in the li

SUBMITTER: Bai X 

PROVIDER: S-EPMC7487607 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature