Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis.

ABSTRACT:

Background

Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer's disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mechanisms governing astrocytic response and their precise role in countering Aβ deposition remain ill-defined. Peroxiredoxin (PRDX) 6 is an enzymatic protein with independent glutathione peroxidase (Gpx) and phospholipase A2 (PLA₂) activities involved in repair of oxidatively damaged cell membrane lipids and cellular signaling. In the CNS, PRDX6 is uniquely expressed by astrocytes and its exact function remains unexplored.

Methods

APPswe/PS1_dE9 AD transgenic mice were once crossed to mice overexpressing wild-type Prdx6 allele or to Prdx6 kno

SUBMITTER: Pankiewicz JE 

PROVIDER: S-EPMC7487614 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature