Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis.

ABSTRACT:

Background

Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear.

Methods

With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 and GSE7956 were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the differentially expressed gene (DEG) of primary melanoma and metastatic melanoma, three kinds of analyses were performed, namely functional annotation, protein-protein interaction (PPI) network and module construction, and co-expression and drug-gene interaction prediction analysis.

Results

A total of 41 up-regulated genes and 79 down-regulated genes was sele

SUBMITTER: Su W 

PROVIDER: S-EPMC7487637 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature