Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.

ABSTRACT:

Background

Colorectal cancer (CRC) development is generally accepted as a sequential process, with genetic mutations determining phenotypic tumor progression. However, matching genetic profiles with histological transition requires the analyses of temporal samples from the same patient at key stages of progression.

Results

Here, we compared the genetic profiles of 34 early carcinomas with their respective adenomatous precursors to assess timing and heterogeneity of driver alterations accompanying the switch from benign adenoma to malignant carcinoma. In almost half of the cases, driver mutations specific to the carcinoma stage were not observed. In samples where carcinoma-specific alterations were present, TP53 mutations and chromosome 20 copy gains commonly accompanied the

SUBMITTER: Mamlouk S 

PROVIDER: S-EPMC7487684 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature