A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing.

ABSTRACT:

Background

Stem cell therapies have gained great attention for providing novel solutions for treatment of various injuries and diseases due to stem cells' self-renewal, ability to differentiate into various cell types, and favorite paracrine function. Nevertheless, the low retention of transplanted stem cell still limits their clinical applications such as in wound healing in view of an induced harsh microenvironment rich in reactive oxygen species (ROS) during inflammatory reactions.

Methods

Herein, a novel chitosan/acellular dermal matrix (CHS/ADM) stem cell delivery system is developed, which is of great ROS scavenging activity and significantly attenuates inflammatory response.

Result

Under ROS microenvironment, this stem cell delivery system acts as a barrier, ef

SUBMITTER: Lin W 

PROVIDER: S-EPMC7487689 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature