MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population.

ABSTRACT:

Background

Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most common genetic variants studied are SNPs (Single Nucleotide Polymorphisms) that determine susceptibility to an array of diseases thus serving as a potential tool for identifying the underlying causes of breast carcinogenesis.

Methods

SNP genotyping employing the Agena MassARRAY offers a robust, sensitive, cost-effective method to assess multiple SNPs and samples simultaneously. In this present study, we analyzed 15 SNPs of 14 genes in 550 samples (150 cases and 400 controls). We identified four SNPs of genes TCF21, SLC19A1, DCC, and ERCC1 showing significant assoc

SUBMITTER: Bakshi D 

PROVIDER: S-EPMC7487711 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature