Bone mineral density and bone microarchitecture in a cohort of patients with Erdheim-Chester Disease.

ABSTRACT:

Background

Erdheim-Chester Disease (ECD) is a rare type of non-Langerhans histiocytosis. Skeletal structures are affected in over 95% ECD patients. Due to the lack of proper imaging assessment tools, the alteration of bone microarchitecture in ECD has not been well studied. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed assessment of bone mineral density and bone microarchitecture.

Methods

We performed a cross-sectional study with 13 patients diagnosed with ECD in Peking Union Medical College Hospital between October 2018 and June 2019. The diagnosis of ECD was based on typical pathological findings in the context of appropriate clinical and radiological manifestations. Bone geometry, volumetric bone mineral density and bone microa

SUBMITTER: He T 

PROVIDER: S-EPMC7487812 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature