Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns.

ABSTRACT:

Background

Intrauterine exposure to a disturbed maternal glucose metabolism is associated with adverse offspring outcomes. DNA methylation is a potential mechanism underlying these associations. We examined whether maternal early-pregnancy glucose and insulin concentrations are associated with newborn DNA methylation. In a population-based prospective cohort study among 935 pregnant women, maternal plasma concentrations of non-fasting glucose and insulin were measured at a median of 13.1 weeks of gestation (95% range 9.4-17.4). DNA methylation was measured using the Infinium HumanMethylation450 BeadChip (Ilumina). We analyzed associations of maternal early-pregnancy glucose and insulin concentrations with single-CpG DNA methylation using robust linear regression models. Differentia

SUBMITTER: Geurtsen ML 

PROVIDER: S-EPMC7487846 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature