Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy worldwide. However, the molecular events underlying IgAN remain to be fully elucidated. This study aimed to identify novel biomarkers of IgAN through bioinformatics analysis and elucidate the possible molecular mechanism.

Methods

Based on the microarray datasets GSE93798 and GSE37460 downloaded from the Gene Expression Omnibus database, the differentially expressed genes (DEGs) between IgAN samples and normal controls were identified. Using the DEGs, we further performed a series of functional enrichment analyses. Protein-protein interaction (PPI) networks of the DEGs were constructed using the STRING online search tool and were visualized using Cytoscape. Next, hub genes were identified

SUBMITTER: Jiang X 

PROVIDER: S-EPMC7487908 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature