Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa).

ABSTRACT:

Background

RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of RNA editing in the pineal gland (PG), a small neuroendocrine gland that synthesizes and secretes melatonin, which is primarily responsible to modulate sleep patterns.

Results

This study analyzed the expression of adenosine-to-inosine (A-to-I) editing regulators and profiled the first dynamic A-to-I RNA editome during postnatal PG development. The results identified ADAR1 as the most abundantly expressed ADAR enzyme, which was down-regulated during postnatal PG development. Furthermore, 47,284 high-confidence RNA

SUBMITTER: Zhou R 

PROVIDER: S-EPMC7487922 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature