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Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water.

ABSTRACT: We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.

SUBMITTER: Xue W

PROVIDER: S-EPMC7487980 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water.

Xue Weijian W Zavalij Peter Y PY Isaacs Lyle L

Angewandte Chemie (International ed. in English) 20200615 32

We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents. ...[more]

PMID: 32413198

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