A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.

ABSTRACT:

Background

Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4⁺ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region (Tax) is important for initiating malignant transformation, and deregulation of the major signaling pathway nuclear factor of kappa B (NF-κB) by Tax represents a hallmark of HTLV-1 driven cancer.

Results

Here we found that Tax mutants which are defective in NF-κB signaling showed diminished protein expression levels compared to Tax wildtype in T-cells, whereas Tax transcript levels were comparable. Strikingly, constant activation of NF-κB signaling by the constitutive active mut

SUBMITTER: Millen S 

PROVIDER: S-EPMC7488018 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature