Comprehensive host-pathogen protein-protein interaction network analysis.

ABSTRACT:

Background

Infectious diseases are a cruel assassin with millions of victims around the world each year. Understanding infectious mechanism of viruses is indispensable for their inhibition. One of the best ways of unveiling this mechanism is to investigate the host-pathogen protein-protein interaction network. In this paper we try to disclose many properties of this network. We focus on human as host and integrate experimentally 32,859 interaction between human proteins and virus proteins from several databases. We investigate different properties of human proteins targeted by virus proteins and find that most of them have a considerable high centrality scores in human intra protein-protein interaction network. Investigating human proteins network properties which are targeted by d

SUBMITTER: Khorsand B 

PROVIDER: S-EPMC7488060 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature