High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis.

ABSTRACT:

Background

BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting results and insufficient sampling, a meta-analysis was performed to explore the prognostic value of BANCR in various carcinomas.

Methods

A comprehensive literature search of PubMed, Web of Science, EMBASE, Cochrane Library and the China National Knowledge Infrastructure (CNKI) was conducted to collect relevant articles.

Results

The pooled results showed a strong relationship between high BANCR expression and poor overall survival (OS) (HR (hazard ratio) =1.60, 95% confidence interval (CI): 1.19-2.15, P = 0.002) and recurrence-free survival (RFS) (HR = 

SUBMITTER: Fang S 

PROVIDER: S-EPMC7488167 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature