Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan.

ABSTRACT:

Background

GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, to our knowledge, none have examined disease progression after delivery or obstetric complications.

Objective

This study aimed to reveal maternal complications, newborn complications, and the impact of pregnancy on disease progression in GNE myopathy patients.

Methods

We conducted a questionnaire survey on pregnancy, delivery, and newborns involving female GNE myopathy patients who are currently registered in a national registry in Japan.

Results

The response rate for the questionnaire survey was 60.0% (72/120). Of the 72 respondents, 44 (61.1%) had pregnancy experience (average, 1.8 pregnancies

SUBMITTER: Yoshioka W 

PROVIDER: S-EPMC7488253 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature