Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.

ABSTRACT:

Background

Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals of European ancestry, but the v8 release also includes up to 15% of individuals of non-European ancestry. Assessing ancestry-based adjustments in GTEx improves portability of this research across populations and further characterizes the impact of population structure on GWAS colocalization.

Results

Here, we identify a subset of 117 individuals in GTEx (v8) with a high degree of population admixture and estimate genome-wide local ancestry. We perform genome-wide cis-eQTL mapping using admixed samples in seven tissues, adjusted by either global or l

SUBMITTER: Gay NR 

PROVIDER: S-EPMC7488497 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature