Subjective cognitive decline, anxiety symptoms, and the risk of mild cognitive impairment and dementia.

ABSTRACT:

Background

Subjective cognitive decline (SCD) and anxiety symptoms both predict neurocognitive disorders, but the two correlate strongly with each other. It is unclear whether they reflect two independent disease processes in the development of neurocognitive disorders and hence deserve separate attention. This cohort study examined whether SCD and anxiety symptoms demonstrate independent risks of mild cognitive disorder and dementia (MCI/dementia).

Methods

The study included 14,066 participants aged ≥ 50 years and diagnosed with normal cognition at baseline, recruited from Alzheimer's Disease Centers across the USA. The participants were evaluated for SCD and anxiety symptoms at baseline and followed up almost annually for incident MCI/dementia (median follow-up 4.5 years;

SUBMITTER: Liew TM 

PROVIDER: S-EPMC7488541 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature