A new childhood ALL case with an extremely complex karyotype and acute spontaneous tumor lysis syndrome.

ABSTRACT:

Background

B cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood, with, after corresponding treatment, an overall complete remission rate of 90%. Approximately 75% of B-ALL cases harbor recurrent abnormalities, including so-called complex karyotypes (CK). Tumor lysis syndrome (TLS) is a metabolic abnormality which may arise during cancer therapy and also, extremely rarely, as spontaneous TLS before initiation of chemotherapy in patients with ALL.

Case presentation

Here we report a 9-year-old male, diagnosed with a de novo pre-B-ALL according to the WHO classification. Cytogenetic, molecular cytogenetic approaches and array comparative genomic hybridization analyses revealed a unique CK involving five chromosomes. It included four ye

SUBMITTER: Wafa A 

PROVIDER: S-EPMC7488544 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature