Ultrathin gold nanowires to enhance radiation therapy.

ABSTRACT:

Background

Radiation therapy is a main treatment option for cancer. Due to normal tissue toxicity, radiosensitizers are commonly used to enhance RT. In particular, heavy metal or high-Z materials, such as gold nanoparticles, have been investigated as radiosensitizers. So far, however, the related studies have been focused on spherical gold nanoparticles. In this study, we assessed the potential of ultra-thin gold nanowires as a radiosensitizer, which is the first time.

Methods

Gold nanowires were synthesized by the reduction of HAuCl₄ in hexane. The as-synthesized gold nanowires were then coated with a layer of PEGylated phospholipid to be rendered soluble in water. Spherical gold nanoparticles coated with the same phospholipid were also synthesized as a compariso

SUBMITTER: Bai L 

PROVIDER: S-EPMC7488570 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature