Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration.

ABSTRACT:

Background

A protein exhibiting more than one biochemical function is termed a moonlighting protein. Glycolytic enzymes are typical moonlighting proteins, and these enzymes control the infection of various viruses. Previously, we reported that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and alpha-enolase (ENO1) are incorporated into human immunodeficiency virus type 1 (HIV-1) particles from viral producer cells and suppress viral reverse transcription independently each other. However, it remains unclear whether these proteins expressed in viral target cells affect the early phase of HIV-1 replication.

Results

Here we show that the GAPDH expression level in viral target cells does not affect the early phase of HIV-1 replication, but ENO1 has a capacity to suppress viral

SUBMITTER: Kishimoto N 

PROVIDER: S-EPMC7488571 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature